SB-431542

仅用于工业应用或科学研究，不可用于人类或动物的临床诊断或治疗，非药用.SB-431542 is a TGF-β receptor kinase inhibitor （TRKI）. SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways.SB-431542 是 TGF-β 受体激酶抑制剂 （TRKI）。SB-431542 对 ALK4、ALK5 和 ALK7 活性有抑制作用， IC50 值分别为 1 μM、0.75 μM 和 2 μM。SB-431542 还能抑制 TGF-β 诱导的转录、基因表达、细胞凋亡和生长抑制。SB-431542 可用于癌症及其信号转导途径的研究